The Biochemical and Hematological Alterations in Patients Infected with Falciparum Malaria Attending General Hospital Barkin/Ladi, Plateau State, Nigeria.
These studies seek to investigate alterations in biochemical and haematologic indices of malaria infected inhabitants of Barkin Ladi. Methods. Malaria parasite, Biochemical and haematologic changes were estimated by microscopy, reflotron plus dry chemistry analyzer and SYSMEX KX-21N haematology analyze respectively. A total of 97 persons were enrolled for the study out of which 67 persons were malaria positive and 30 persons were malaria negative (control group). Result. Liver enzymes; Alanine amino transferase (ALT), Aspartate serum transferase (AST) were significantly higher in malaria positive group 31.62 and 36.05 (ų/L) respectively compared to the control group 7.89 and 2.68 (ų/L) respectively. Total bilirubin, creatinine, and urea level were significantly higher in malaria infected group 2.68, 1.14 and 21.37 (mg/dL) compared to non infected group 1.44, 0.54 and 12.73 (mg/dL) respectively. Albumin concentration in malaria positive group were lower 3.21 (mg/dL) compared to the control group 4.64 (mg/dL). The haemoglobin concentration (g/dl), PCV (%), RBC x106, platelets x10³ in malaria infected group was significantly lower 10.84 (g/dL), 25.14 (%), 3.69 (/ųL) and 69.26 (/ųL) compared tonon infected group 26.87(g/dL),, 25.95(%), 6.39 (/ųL) and 221.67(/ųL) respectively. WBC and white blood cell components, ESR (mm/h), MCV (fl) and MCH (pg/cell) concentrations were significantly higher in malaria infected individuals 13.85, 28.80 (mm/h), 80.48(fl), and 66.45(pg/cell), compared to non infected group 8.87, 19.11(mm/h), 59.85(fl), and 22.95(pg/cell). Conclusion This study concluded that the malaria infection has alteration on haematological parameters and immense impact on the liver and kidney function especially among those who were severely infected.